The Gottschalk-Gleser content analysis method provides a means of making many kinds of measurements in psychology and neuropsychiatry, including the measurement of psychological changes, making initial diagnostic formulations, providing suggestions for further evaluations (if necessary), and serving as guidelines for possible therapeutic interventions. It has been used in psychotherapy research to measure changes occurring in adults and children during the process of therapy, to predict psychotherapeutic outcome, to evaluate psychotherapeutic outcome, to assess the importance of defense mechanisms (such as displacement and denial) in different diagnostic groups of clients, and even to teach psychodynamic psychotherapy. It has been used to measure the relative severity of many mental and neuropsychiatric disorders, such as anxiety disorders, schizophrenia, depression, and dementia in aging and with alcohol abuse, and cognitive impairment associated with other drugs, such as, marijuana and the benzodiazepines. It has been used in and recommended for psychosomatic research. It has been used to study the effects of partial and total body irradiation and sensory overload. It has proven to be very useful in neuropsychopharmacological studies, such as in the testing of new anti-anxiety drugs, the effects of major tranquilizers, antidepressants, analgesics, and in studying the relationship of the pharmacokinetics of psychoactive drugs and clinical response. It has been widely used to assess the emotional status of medically ill patients, for example, in diabetes mellitus, with bruxism, with mastectomy for breast cancer and with cholecystectomy, and with attention-deficit-hyperactive children. More recently it has been used to assess the quality of life as well as the relationship of cerebral glucose metabolic rates (as assessed by positron emission tomography) and emotions occurring during dreams or silent wakeful mentation or while feeling hopeful or hopeless. Two other interesting applications of this content analysis method involved reviewing and demonstrating its cross-cultural validity and using it to assess the relative degree of cognitive impairment manifested by presidential candidates during their campaign debates.